Pakistan left-arm spinner Noman Ali took four wickets for 85 runs as South Africa reached 216-6 in the first test.
Left-handed Tony de Zorzi showed composure against the spinners on a tricky wicket.
Pakistan's spinners proved challenging for South Africa's batters.
The match is being played on an abrasive wicket, making it difficult for batters.
Author's summary: South Africa struggles against Pakistan spinners in first test.