Turbocharging Cas9’s Nuclear Entry
Gene editing efficiency is boosted by a new nuclear localization signal strategy, as reported by Christopher Doyle, PhD.
A major challenge in CRISPR-based therapies is successfully targeting and gaining entrance to the nucleus, which contains the cell’s genetic information in the form of DNA.
Advanced engineered cell therapies require gene editing tools that are both precise and efficient. CRISPR-Cas9 has emerged as the gold standard for editing genes with greater precision than older techniques.
Unlike viral vectors, Cas9 and similar endonucleases cut DNA at specific sites, allowing for controlled modifications.
Author's summary: Gene editing efficiency is boosted.